Can I take Ayahuasca
if I have depression?

Many people with depression are afraid to take Ayahuasca because they assume it can worsen their mental state. At the same time, they also think that depression will make the ceremonial experience unpleasant and scary.
Let's see if it is actually true.

APL Shamanic Journeys retreats blog

Is it true that I should avoid taking Ayahuasca
if I'm depressed?

Depression is a severe mental challenge that affects tons of people worldwide. While many sufferers turn to traditional therapy and medication, a growing number are exploring alternative solutions, including Ayahuasca. But can this traditional Amazonian medicine actually help with depression, or will it make it worse?

To understand the effectiveness of Ayahuasca in treating depression, it's important to examine its composition. Ayahuasca is made from two main components: the Ayahuasca vine (Banisteriopsis caapi) and one of three plants - Psychotria Viridis (Chacruna), Mimosa tenuiflora (Jurema), or Diplopterys cabrerana (Chaliponga). The Ayahuasca vine contains three monoamine oxidase inhibitors (MAOIs), while the plants contain N, N-Dimethyltryptamine (DMT), the main psychoactive compound.

When consumed, the MAOIs in the Ayahuasca vine block the enzyme that breaks down DMT, allowing it to become orally active. At the same time, the MAOIs also regulate neurotransmitters such as serotonin, dopamine, and noradrenaline. This is why it's crucial to be free of SSRIs and other drugs before taking Ayahuasca. Combining SSRIs with the MAOIs in Ayahuasca can lead to an adverse reaction and even serotonin syndrome, which can be life-threatening.

While the risks of Ayahuasca use should not be taken lightly, the benefits are clear. Research has shown that Ayahuasca can help regulate neurotransmitters, leading to a reduction in symptoms of depression. Additionally, the powerful hallucinations experienced during an Ayahuasca ceremony can provide a unique perspective on one's life and beliefs, leading to greater self-awareness and growth.

If you're considering Ayahuasca retreat in Mexico, Europe, Peru or any other country for depression, it's crucial to follow proper preparation guidelines. This includes tapering off any medication in advance and consulting with a doctor before making any changes to your treatment plan. With the right support and preparation, Ayahuasca can be a powerful tool in the journey toward healing and personal growth.

Ok, now you are free from antidepressants, how Ayahuasca is going to help you with your depression?

Surprisingly, contrary to popular belief, DMT isn't the main factor in producing an antidepressant effect in Ayahuasca, although it does affect certain receptors in the brain that help fight depression. The spiritual experience and the shaman's role during the ceremony also play a big part in the healing process.

The real magic happens with the B-Carbolins (MAOIs) found in the brew. Studies have shown that harmine and other harmala alkaloids (which inhibit MAO) have been used as antidepressants for a long time and have been proven to improve mood and reduce anxiety.

Not only that, but taking MAOIs (harmine) over a long period of time has been shown to reduce depression symptoms, increase well-being, and even stimulate the growth of new brain cells!

Recent studies have also shown that just one Ayahuasca session can increase blood flow to brain regions that regulate mood and emotions, and decrease activity in the Default Mode Network, which is known to be overactive in depression.

And if that's not enough, evaluations of regular Ayahuasca users over the past 20 years have shown improved cognitive function, reduced anxiety and depressive symptoms, and increased overall well-being compared to non-users. Plus, a recent study even found that a single dose of Ayahuasca can boost mindfulness.

So, while DMT may not be the main factor, there's definitely a lot more to Ayahuasca and its potential to fight depression than meets the eye!

Can Ayahuasca help me to cope with depression?

The good news is, the answer is yes! In fact, in some cases, Ayahuasca can be even more effective than traditional antidepressant medications.

Ayahuasca has been used for centuries as a healing tool in the Amazon, and it's a great way to address both physical and mental imbalances. By affecting the way your brain works, Ayahuasca can help you find balance and healing.
Plus, the spiritual journey during the ceremony allows you to delve deep into your inner self and uncover the root causes of your depression. It's an opportunity to understand what's holding you back and find a path forward.

And even if you're worried that your depression might make the Ayahuasca experience difficult, don't be! Sometimes, the most challenging ceremonies are also the most healing. Ayahuasca can help you revisit past traumas and emotions so you can let go of them and move forward.

Just make sure you're properly prepared for the ceremony and understand how to minimize any potential risks. With the right preparation and a supportive environment, Ayahuasca can be a powerful tool in your journey towards healing and recovery from depression

Boris
03.07.2020
Sources:

1) Toxicokinetics and Toxicodynamics of Ayahuasca Alkaloids N,N-Dimethyltryptamine (DMT), Harmine, Harmaline and Tetrahydroharmine: Clinical and Forensic Impact by Andreia Machado Brito-da-Costa,1 Diana Dias-da-Silva,1,2,* Nelson G. M. Gomes,1,3 Ricardo Jorge Dinis-Oliveira,1,2,4,*and  Áurea Madureira-Carvalho1,3

2) Rapid antidepressant effects of the psychedelic ayahuasca in treatment-resistant depression: a randomized placebo-controlled trial by Fernanda Palhano-Fontes,1,2 Dayanna Barreto,2,3 Heloisa Onias,1,2 Katia C. Andrade,1,2 Morgana M. Novaes,1,2Jessica A. Pessoa,1,2 Sergio A. Mota-Rolim,1,2 Flávia L. Osório,4,5 Rafael Sanches,4,5 Rafael G. dos Santos,4,5Luís Fernando Tófoli,6 Gabriela de Oliveira Silveira,7 Mauricio Yonamine,7 Jordi Riba,8 Francisco R. Santos,9Antonio A. Silva-Junior,9 João C. Alchieri,10 Nicole L. Galvão-Coelho,5,11 Bruno Lobão-Soares,5,12Jaime E. C. Hallak,4,5 Emerson Arcoverde,2,3,5 João P. Maia-de-Oliveira,2,3,5 and  Dráulio B. Araújo1,2

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